Systematic Review

Optimal treatment strategy for mixed arteriovenous leg ulceration: a systematic review protocol

February 27, 2025

Introduction Chronic leg ulceration is an increasingly common condition affecting 1.5% of all adults and 3–5% over the age of 60. It is a major challenge to healthcare systems due to the high cost of managing patients with this condition.1 The National Health Service (NHS) in England treats an estimated 700,000 leg ulcers annually, costing…

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The incidence of surgical site infection following transmetatarsal amputation: a systematic review

August 18, 2024

Introduction Transmetatarsal amputations (TMAs) were first popularised in 1949 by McKittrick et al, who used this procedure as an alternative to more proximal amputations when addressing gangrene or infection.1 Its use has continued as an effective surgical approach in treating forefoot gangrene, infection and chronic ulceration, most commonly in patients with diabetic foot or vascular…

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Home-based high intensity interval training in patients with intermittent claudication: a systematic review protocol

April 24, 2024

Introduction and rationale Peripheral arterial disease (PAD) is caused by atherosclerosis of the arteries supplying the lower limbs, limiting blood flow to the legs.1 PAD is estimated to affect more than 237 million people worldwide and its prevalence is increasing.2 Intermittent claudication (IC) is the classical symptom of PAD, and is characterised by a reproducible…

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Changes in functional health status following open abdominal aortic aneurysm repair and the role of exercise-based rehabilitation: a systematic review

November 20, 2023

Introduction Patients with abdominal aortic aneurysms (AAA) are usually older adults with widespread atherosclerosis and considerable cardiovascular risk factors.1–3 As a result, open surgical repair is associated with significant perioperative morbidity which may require a prolonged inpatient or intensive care stay.4,5  The associated metabolic and cardiopulmonary challenges may have substantial resultant consequences on functional status…

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