Reviews
Psychological needs of individuals with peripheral arterial disease: a narrative review
Introduction Peripheral arterial disease (PAD) is an atherosclerotic occlusive process that involves the arteries of the extremities and burdens up to a quarter of a billion individuals globally. It is ranked as the third leading cause of atherosclerotic morbidity after coronary artery disease and stroke, making it one of the leading causes of disability. The…
Carotid webs: a review of diagnosis and management strategies in current literature
Introduction Carotid Webs (CaW) are non-atherosclerotic fibrous bands which present as shelf-like linear intraluminal filling defects, often on the posterior wall of the carotid bulb or the proximal internal carotid artery, causing turbulent flow (Figures 1-5).1-4 The condition was first described by Ehrenfeld in 1967 and is often referred to as atypical fibromuscular dysplasia…
Safety and efficacy of tranexamic acid in major non-cardiac vascular surgery: a systematic review and meta-analysis
Introduction Tranexamic acid (TXA) is a synthetic lysine analogue that inhibits the conversion of plasminogen to plasmin, thereby inhibiting fibrinolysis.1 Large pragmatic randomised controlled trials (RCTs) have demonstrated that TXA is associated with a reduction in mortality in patients with major traumatic haemorrhage,2 postpartum haemorrhage3 and mild to moderate traumatic brain injury4; reduced transfusion requirements…
A contemporary review of the diagnosis and management of vascular Ehlers–Danlos syndrome
Introduction Ehlers–Danlos syndrome (EDS) is a recognised connective tissue disorder that affects collagen and extracellular matrix function. EDS is a cluster of 13 inherited conditions/types (19 different causal genes) which vary in incidence, clinical presentation and natural history.1 The most common of these is that of hypermobile EDS which has an incidence of approximately 1:10,000…
