bleeding
A national UK-wide survey of tranexamic acid use in vascular surgery
Introduction Tranexamic acid (TXA) is a synthetic lysine analogue that inhibits fibrinolysis and reduces surgical bleeding by stabilising clot formation.1 Large randomised trials have demonstrated its efficacy in a range of clinical settings including trauma, postpartum haemorrhage and cardiac surgery, where TXA has been associated with reductions in mortality, critical bleeding and transfusion requirements.2-5 National…
Safety and efficacy of tranexamic acid in major non-cardiac vascular surgery: a systematic review and meta-analysis
Introduction Tranexamic acid (TXA) is a synthetic lysine analogue that inhibits the conversion of plasminogen to plasmin, thereby inhibiting fibrinolysis.1 Large pragmatic randomised controlled trials (RCTs) have demonstrated that TXA is associated with a reduction in mortality in patients with major traumatic haemorrhage,2 postpartum haemorrhage3 and mild to moderate traumatic brain injury4; reduced transfusion requirements…
