chronic limb-threatening ischaemia
An audit of Global Vascular Guidelines implementation at two large teaching hospitals in differing healthcare settings
Introduction Chronic limb-threatening ischaemia (CLTI) is the most severe form of peripheral arterial disease, associated with high rates of morbidity, mortality, and limb loss.1 CLTI creates significant costs to healthcare systems across the globe. Between 2020 and 2021 alone, the financial burden of non-elective amputations cost the National Health Service (NHS) over £115 million.2 Therefore,…
Read MoreSurgical Site Infection in Major Lower Limb Amputation (SIMBA): an international multicentre audit: baseline unit survey
Introduction Surgical site infections (SSIs) are a common complication following any surgical procedure, accounting for 20% of all hospital-associated infections.1 The incidence of SSI following major lower limb amputation (MLLA) is particularly high, with a recent systematic review reporting an overall incidence of 7.2% and single-centre studies reporting rates up to 27%.2 SSIs are a…
Read MoreModels of same-day emergency care for vascular limb salvage
Introduction The efficient and effective management of patients with chronic limb-threatening ischaemia (CLTI) is a challenge for UK vascular services, due to the volume and complexity of patients and centralisation of services.1,2 In an attempt to provide comprehensive limb salvage services in keeping with the global vascular guidelines,3 more than 14,000 revascularisation procedures are performed…
Read MorePrognostic value of simple frailty and malnutrition screening tools for determining surgical risk in patients with chronic limb threatening ischaemia undergoing major vascular surgery: a retrospective cross-sectional study
Introduction Chronic limb threatening ischaemia (CLTI) is a severe manifestation of peripheral arterial disease (PAD), characterised by intractable rest pain with or without tissue loss in the form of ulceration and/or gangrene or infection.1 Approximately 1% of all PAD cases are due to CLTI and first-line treatment includes revascularisation, primary amputation or, in some cases,…
Read MoreSingle-centre prospective cohort study investigating the associations and one-year trends of frailty, cognition, disability and quality of life pre- and post-intervention for chronic limb-threatening ischaemia
Introduction Frailty is a complex, dynamic, multi-system health state characterised by susceptibility to significant homeostatic dysregulation from even minor physiological stressors, leading to poor health-related outcomes such as loss of independence and death.1,2 Frailty is present in around half of all individuals with chronic limb-threatening ischaemia (CLTI) and is related to severity of disease.3-5 Among…
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