thromboembolism blood transfusion

Introduction Tranexamic acid (TXA) is a synthetic lysine analogue that inhibits the conversion of plasminogen to plasmin, thereby inhibiting fibrinolysis.1 Large pragmatic randomised controlled trials (RCTs) have demonstrated that TXA is associated with a reduction in mortality in patients with major traumatic haemorrhage,2 postpartum haemorrhage3 and mild to moderate traumatic brain injury4; reduced transfusion requirements…