Trial Protocols

Does the level of encouragement affect 6-minute walk test performance in patients with intermittent claudication? A protocol for a randomised multicentre controlled trial

May 16, 2022

Introduction Peripheral artery disease (PAD) is characterised by atherosclerotic lesions of the arteries in the lower limbs, resulting in a reduction of blood flow.1 Globally, it is estimated that 236 million people are living with PAD, with the number of cases increasing by 24% from 2000 to 2010.2,3 A classic symptom of PAD is intermittent…

VENUM (Vascular Education iN Undergraduate Medicine) Protocol

May 11, 2022

Background Peripheral arterial disease (PAD) is most commonly an atherosclerotic condition affecting the lower limbs, which usually manifests as muscle pain during exertion.1 The gold standard of PAD diagnosis, an ankle brachial pressure index (ABPI) of <0.9, can be done at the bedside.1 PAD affects up to 5% of patients aged 60–69 years, increasing to…

Community WALKing and home-baSed circuiT tRaining in peOple liviNG with intermittent claudication (WALK-STRONG): protocol for a randomised controlled feasibility trial

May 11, 2022

Introduction Peripheral artery disease (PAD) refers to the progressive occlusion of the arteries supplying the lower limbs1 and affects over an estimated 236 million people worldwide.2 Sustained ischaemia to the lower limbs, resulting in an oxygen supply/demand imbalance, can lead to a symptomatic presentation of PAD, characterised by exertional cramp-like leg pain known as intermittent…