James Lind Alliance

Research priorities for patients with peripheral arterial disease: a James Lind Alliance Priority Setting Partnership

February 11, 2022

Introduction Peripheral arterial disease (PAD) is an atherosclerotic process whereby the arteries supplying the lower limbs become narrowed or occluded. PAD is an increasingly common disease, estimated to affect 237 million people, with an increase of 45% between 2000 and 2015.1,2 The PAD spectrum is wide and ranges from asymptomatic, whereby the patient is often…

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Research priorities for lower limb amputation in patients with vascular disease

November 24, 2021

Introduction Over 4,000 major lower limb amputations (MLLA) are performed per annum in the UK1 for end-stage lower limb arterial disease or profound foot sepsis. Amputation is a significant life event for patients and their carers/families. Although supported by recommendations for optimal practice,2 MLLA can be associated with high mortality and complication rates.3,4 The process…

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